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SIGIRR antibody (C-Term)

SIGIRR Reactivity: Human, Mouse, Rat, Horse, Zebrafish (Danio rerio), Cow, Dog, Guinea Pig, Pig WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2783841
  • Target See all SIGIRR Antibodies
    SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
    Binding Specificity
    • 8
    • 6
    • 3
    • 3
    • 2
    • 2
    C-Term
    Reactivity
    Human, Mouse, Rat, Horse, Zebrafish (Danio rerio), Cow, Dog, Guinea Pig, Pig
    Host
    • 25
    • 4
    • 1
    Rabbit
    Clonality
    • 25
    • 5
    Polyclonal
    Conjugate
    • 22
    • 6
    • 2
    This SIGIRR antibody is un-conjugated
    Application
    • 28
    • 13
    • 10
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    PVFGEPSAPP HTSGVSLGES RSSEVDVSDL GSRNYSARTD FYCLVSKDDM
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 86%
    Characteristics
    This is a rabbit polyclonal antibody against SIGIRR. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human SIGIRR
    Top Product
    Discover our top product SIGIRR Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 224 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
    Alternative Name
    SIGIRR (SIGIRR Products)
    Synonyms
    TIR8 antibody, AI256711 antibody, sc:d148 antibody, RGD1306732 antibody, single Ig and TIR domain containing antibody, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain antibody, SIGIRR antibody, Sigirr antibody, sigirr antibody
    Background
    SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. Through its extracellular domain it interferes with the heterodimerization of Il1R1 and IL1RAP.
    Alias Symbols: MGC110992, TIR8
    Protein Interaction Partner: APP, UBC, SIGIRR, TLR9, TLR5, TLR4, TRAF6, IRAK1, RPN1, IL1R1, ENO2,
    Protein Size: 224
    Molecular Weight
    25 kDa
    Gene ID
    59307
    UniProt
    Q6IA17
    Pathways
    Toll-Like Receptors Cascades
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