SMUG1 antibody (AA 1-177)
Quick Overview for SMUG1 antibody (AA 1-177) (ABIN7169740)
Target
See all SMUG1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 1-177
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Cross-Reactivity
- Human
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Purification
- >95%, Protein G purified
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Immunogen
- Recombinant Human Single-strand selective monofunctional uracil DNA glycosylase protein (1-177AA)
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Isotype
- IgG
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- SMUG1 (Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1 (SMUG1))
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Alternative Name
- SMUG1
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Background
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Background: Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration.
Aliases: FDG antibody, HMUDG antibody, MGC104370 antibody, Single strand selective monofunctional uracil DNA glycosylase 1 antibody, Single strand selective monofunctional uracil DNA glycosylase antibody, Single-strand selective monofunctional uracil DNA glycosylase antibody, SMUG 1 antibody, Smug1 antibody, SMUG1 protein antibody, SMUG1_HUMAN antibody, UNG 3 antibody, UNG3 antibody
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UniProt
- Q53HV7
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Pathways
- DNA Damage Repair
Target
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