Sonic Hedgehog antibody (AA 51-300)

Catalog No. ABIN7170326

This Rabbit Polyclonal antibody specifically detects Sonic Hedgehog in ELISA and IF. It exhibits reactivity toward Human.

Quick Overview for Sonic Hedgehog antibody (AA 51-300) (ABIN7170326)

Target: Sonic Hedgehog (SHH)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Sonic Hedgehog antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Product Details anti-Sonic Hedgehog Antibody

Binding Specificity: AA 51-300

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Sonic hedgehog protein (51-300AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Sonic Hedgehog

Target: Sonic Hedgehog (SHH)

Alternative Name: SHH

Background:

Background: Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity).

Aliases: HHG 1 antibody, HHG-1 antibody, HHG1 antibody, HLP 3 antibody, HLP3 antibody, Holoprosencephaly 3 antibody, HPE 3 antibody, HPE3 antibody, MCOPCB5 antibody, shh antibody, SHH_HUMAN antibody, SMMC I antibody, SMMCI antibody, Sonic Hedgehog (Drosophila) homolog antibody, sonic hedgehog homolog (Drosophila) antibody, Sonic hedgehog homolog antibody, Sonic hedgehog protein antibody, Sonic hedgehog protein C-product antibody, TPT antibody, TPTPS antibody

UniProt: Q15465

Pathways: Hedgehog Signaling, Dopaminergic Neurogenesis, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development