CXCL12 antibody (AA 22-89)

Catalog No. ABIN7170825

Product Details anti-CXCL12 Antibody

Target: CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

Binding Specificity: AA 22-89

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXCL12 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: >95%, Antigen Affinity purified & Affinity purified

Immunogen: Recombinant Human Stromal cell-derived factor 1 protein (22-89AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CXCL12

Target: CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

Alternative Name: CXCL12 (CXCL12 Products)

Synonyms: IRH antibody, PBSF antibody, SCYB12 antibody, SDF1 antibody, TLSF antibody, TPAR1 antibody, CINC-1 antibody, Gro1 antibody, Pbsf antibody, Scyb12 antibody, Sdf1 antibody, Tlsf antibody, Tpar1 antibody, Fsp antibody, KC antibody, Mgsa antibody, N51 antibody, Scyb1 antibody, gro antibody, sdf-1 antibody, sdf1 antibody, xSDF-1 antibody, SDF-1 antibody, cxcl12 antibody, sdf-1a antibody, sdf1a antibody, wu:fa55e10 antibody, wu:fc16h12 antibody, wu:fj84c02 antibody, C-X-C motif chemokine ligand 12 antibody, C-X-C motif chemokine ligand 1 antibody, chemokine (C-X-C motif) ligand 12 antibody, chemokine (C-X-C motif) ligand 1 antibody, C-X-C motif chemokine ligand 12 L homeolog antibody, chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) antibody, CXCL12 antibody, cxcl12 antibody, Cxcl1 antibody, Cxcl12 antibody, cxcl12.L antibody, cxcl12a antibody

Background:

Background: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development, required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

Aliases: 12-O-tetradecanoylphorbol 13-acetate repressed protein 1 antibody, AI174028 antibody, C-X-C motif chemokine 12 antibody, Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) antibody, Chemokine (C-X-C motif) ligand 12 antibody, Chemokine CXC motif ligand 12 antibody, cxcl12 antibody, hIRH antibody, hSDF-1 antibody, Intercrine reduced in hepatomas antibody, IRH antibody, OTTHUMP00000019491 antibody, PBSF antibody, Pre-B cell growth-stimulating factor antibody, SCYB12 antibody, SDF 1 antibody, SDF-1 antibody, SDF-1-alpha(3-67) antibody, SDF-1a antibody, SDF-1b antibody, SDF1_HUMAN antibody, SDF1A antibody, SDF1B antibody, Stromal cell-derived factor 1 antibody, Stromal cell-derived factor 1 delta antibody, Stromal cell-derived factor 1 gamma antibody, Stromal cell-derived factor 1a antibody, Stromal cell-derived factor-1 alpha antibody, Thymic lymphoma cell-stimulating factor antibody, Tlsf antibody, TLSF-a antibody, TLSF-b antibody, Tlsfa antibody, Tlsfb antibody, TPAR1 antibody

UniProt: P48061

Pathways: Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling