SMC5 antibody (AA 296-403)

Catalog No. ABIN7170870

The Rabbit Polyclonal anti-SMC5 antibody has been validated for WB and ELISA. It is suitable to detect SMC5 in samples from Human.

Quick Overview for SMC5 antibody (AA 296-403) (ABIN7170870)

Target: SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMC5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SMC5 Antibody

Binding Specificity: AA 296-403

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Structural maintenance of chromosomes protein 5 protein (296-403AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SMC5

Target: SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

Alternative Name: SMC5

Background:

Background: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression, the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).

Aliases: SMC5 antibody, KIAA0594 antibody, SMC5L1 antibody, Structural maintenance of chromosomes protein 5 antibody, SMC protein 5 antibody, SMC-5 antibody, hSMC5 antibody

UniProt: Q8IY18