SMARCB1 antibody (AA 2-376) (FITC)

Catalog No. ABIN7171068

The Rabbit Polyclonal anti-SMARCB1 antibody is suitable to detect SMARCB1 in samples from Human.

Quick Overview for SMARCB1 antibody (AA 2-376) (FITC) (ABIN7171068)

Target: SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMARCB1 antibody is conjugated to FITC

Application: Please inquire

Product Details anti-SMARCB1 Antibody (FITC)

Binding Specificity: AA 2-376

Purpose: SMARCB1 Antibody, FITC conjugated

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 protein (2-376AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SMARCB1

Target: SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1))

Alternative Name: SMARCB1

Background:

Background: Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth By similarity. Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

Aliases: BAF47 antibody, BRG1-associated factor 47 antibody, hSNF5 antibody, INI1 antibody, Integrase interactor 1 protein antibody, Malignant rhabdoid tumor suppressor antibody, RDT antibody, RTPS1 antibody, Sfh1p antibody, SMARCB1 antibody, SNF5 homolog antibody, SNF5_HUMAN antibody, SNF5L1 antibody, Snr1 antibody, Sucrose nonfermenting yeast homolog like 1 antibody, SWI/SNF complex component SNF5 antibody, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 antibody, SWI10 antibody, Transcription factor TYE4 antibody, Transcription regulatory protein SNF5 antibody, TYE4 antibody

UniProt: Q12824