SMARCD3 antibody (AA 2-101) (Biotin)

Catalog No. ABIN7171080

The Rabbit Polyclonal anti-SMARCD3 antibody is suitable to detect SMARCD3 in samples from Human. It has been validated for ELISA.

Quick Overview for SMARCD3 antibody (AA 2-101) (Biotin) (ABIN7171080)

Target: SMARCD3 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily D, Member 3 (SMARCD3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMARCD3 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-SMARCD3 Antibody (Biotin)

Binding Specificity: AA 2-101

Purpose: SMARCD3 Antibody, Biotin conjugated

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 protein (2-101AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SMARCD3

Target: SMARCD3 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily D, Member 3 (SMARCD3))

Alternative Name: SMARCD3

Background:

Background: Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Aliases: 60 kDa BRG 1/Brm associated factor subunit C antibody, 60 kDa BRG-1/Brm-associated factor subunit C antibody, BAF60C antibody, BRG1 associated factor 60C antibody, BRG1-associated factor 60C antibody, Chromatin remodeling complex BAF60C subunit antibody, CRACD3 antibody, Mammalian chromatin remodeling complex BRG1 associated factor 60C antibody, MGC111010 antibody, Rsc6p antibody, Smarcd3 antibody, SMRD3_HUMAN antibody, SWI/SNF complex 60 kDa subunit C antibody, SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily d member 3 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3, isoform 1 antibody, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 antibody, Swp73 like protein antibody

UniProt: Q6STE5

Pathways: Regulation of Lipid Metabolism by PPARalpha