MAPKAP1 antibody (AA 1-290)

Catalog No. ABIN7171521

The Rabbit Polyclonal anti-MAPKAP1 antibody has been validated for WB and ELISA. It is suitable to detect MAPKAP1 in samples from Human.

Quick Overview for MAPKAP1 antibody (AA 1-290) (ABIN7171521)

Target: MAPKAP1 (Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPKAP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MAPKAP1 Antibody

Binding Specificity: AA 1-290

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Target of rapamycin complex 2 subunit MAPKAP1 protein (1-290AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MAPKAP1

Target: MAPKAP1 (Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1))

Alternative Name: MAPKAP1

Background:

Background: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 \\\'Ser-473\\\' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on \\\'Thr-308\\\' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at \\\'Ser-422\\\'. mTORC2 also modulates the phosphorylation of PRKCA on \\\'Ser-657\\\'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.

Aliases: MAPKAP 1 antibody, MAPKAP1 antibody, MEKK2 interacting protein 1 antibody, MGC2745 antibody, MIP 1 antibody, MIP1 antibody, Mitogen activated protein kinase associated protein 1 antibody, Mitogen-activated protein kinase 2-associated protein 1 antibody, mSIN1 antibody, OTTHUMP00000064207 antibody, Ras inhibitor MGC2745 antibody, SAPK interacting protein 1 antibody, SAPK-interacting protein 1 antibody, SIN 1 antibody, SIN1_HUMAN antibody, SIN1b antibody, SIN1g antibody, Stress activated map kinase interacting protein 1 antibody, Stress activated protein kinase interacting 1 antibody, Stress-activated map kinase-interacting protein 1 antibody, Target of rapamycin complex 2 subunit MAPKAP1 antibody, TORC2 subunit MAPKAP1 antibody

UniProt: Q9BPZ7

Pathways: PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events