THO Complex 3 antibody (AA 2-351) (HRP)

Catalog No. ABIN7172054

This Rabbit Polyclonal antibody specifically detects THO Complex 3 in ELISA. It exhibits reactivity toward Human.

Quick Overview for THO Complex 3 antibody (AA 2-351) (HRP) (ABIN7172054)

Target: THO Complex 3 (THOC3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This THO Complex 3 antibody is conjugated to HRP

Application: ELISA

Product Details anti-THO Complex 3 Antibody (HRP)

Binding Specificity: AA 2-351

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human THO complex subunit 3 protein (2-351AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for THO Complex 3

Target: THO Complex 3 (THOC3)

Alternative Name: THOC3

Background:

Background: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5\' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi\'s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

Aliases: hTREX45 antibody, TEX1 homolog antibody, THO complex subunit 3 antibody, Tho3 antibody, THOC3 antibody, THOC3_HUMAN antibody

UniProt: Q96J01