TLR6 antibody (AA 32-586) (HRP)

Catalog No. ABIN7172281

This anti-TLR6 antibody is a Rabbit Polyclonal antibody detecting TLR6 in ELISA. Suitable for Human.

Quick Overview for TLR6 antibody (AA 32-586) (HRP) (ABIN7172281)

Target: TLR6 (Toll-Like Receptor 6 (TLR6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLR6 antibody is conjugated to HRP

Application: ELISA

Product Details anti-TLR6 Antibody (HRP)

Binding Specificity: AA 32-586

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Toll-like receptor 6 protein (32-586AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TLR6

Target: TLR6 (Toll-Like Receptor 6 (TLR6))

Alternative Name: TLR6

Background:

Background: Participates in the innate immune response to bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

Aliases: CD286 antibody, CD286 antigen antibody, TLR 6 antibody, Tlr6 antibody, TLR6_HUMAN antibody, Toll like receptor 6 precursor antibody, Toll-like receptor 6 antibody

UniProt: Q9Y2C9

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades