TRIAP1 antibody (AA 1-76)
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- Target See all TRIAP1 Antibodies
- TRIAP1 (TP53 Regulated Inhibitor of Apoptosis 1 (TRIAP1))
- Binding Specificity
- AA 1-76
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TRIAP1 antibody is un-conjugated
- Application
- ELISA, Immunohistochemistry (IHC)
- Cross-Reactivity
- Human
- Purification
- Antigen Affinity Purified
- Immunogen
- Recombinant Human TP53-regulated inhibitor of apoptosis 1 protein (1-76AA)
- Isotype
- IgG
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- Application Notes
- Recommended dilution: IHC:1:20-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- TRIAP1 (TP53 Regulated Inhibitor of Apoptosis 1 (TRIAP1))
- Alternative Name
- TRIAP1 (TRIAP1 Products)
- Synonyms
- MDM35 antibody, P53CSV antibody, WF-1 antibody, 1810015M01Rik antibody, AU020874 antibody, AU043831 antibody, P53csv antibody, Wf-1 antibody, p53csv-A antibody, triap1 antibody, triap1a antibody, p53csv-B antibody, triap1-a antibody, triap1-b antibody, triap1b antibody, zgc:112025 antibody, TP53 regulated inhibitor of apoptosis 1 antibody, TP53 regulated inhibitor of apoptosis 1 S homeolog antibody, TP53 regulated inhibitor of apoptosis 1 L homeolog antibody, TRIAP1 antibody, Triap1 antibody, triap1.S antibody, triap1.L antibody, triap1 antibody
- Background
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Background: Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003).
Aliases: p53-inducible cell-survival factor antibody, p53CSV antibody, Protein 15E1.1 antibody, TP53-regulated inhibitor of apoptosis 1 antibody, TRIA1_HUMAN antibody, Triap1 antibody, WF 1 antibody, WF1 antibody
- UniProt
- O43715
- Pathways
- Negative Regulation of intrinsic apoptotic Signaling
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