TEAD4 antibody (AA 74-434)

Catalog No. ABIN7172759

This Rabbit Polyclonal antibody specifically detects TEAD4 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for TEAD4 antibody (AA 74-434) (ABIN7172759)

Target: TEAD4 (TEA Domain Family Member 4 (TEAD4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TEAD4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-TEAD4 Antibody

Binding Specificity: AA 74-434

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Transcriptional enhancer factor TEF-3 protein (74-434AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TEAD4

Target: TEAD4 (TEA Domain Family Member 4 (TEAD4))

Alternative Name: TEAD4

Background:

Background: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC \\\'enhansons\\\' (5\\\'-GTGGAATGT-3\\\') and activates transcription. Binds to the M-CAT motif.

Aliases: EFTR 2 antibody, EFTR2 antibody, hRTEF 1B antibody, hRTEF1B antibody, MGC9014 antibody, OTTHUMP00000238119 antibody, OTTHUMP00000238122 antibody, OTTHUMP00000238124 antibody, Related to TEF 1 antibody, Related to TEF1 antibody, Related transcription enhancer factor 1B antibody, RTEF1 antibody, TCF13L1 antibody, TEA domain family member 4 antibody, TEAD 4 antibody, TEAD-4 antibody, TEAD4 antibody, TEAD4_HUMAN antibody, TEF 3 antibody, TEF3 antibody, TEFR 1 antibody, TEFR1 antibody, Transcription factor 13 (SV40 transcriptional enhancer factor) like 1 antibody, Transcription factor 13 like 1 antibody, Transcription factor 13-like 1 antibody, Transcription factor RTEF 1 antibody, Transcription factor RTEF-1 antibody, Transcription factor RTEF1 antibody, Transcriptional enhancer factor 1 related antibody, Transcriptional enhancer factor 3 antibody, Transcriptional enhancer factor TEF 3 antibody, Transcriptional enhancer factor TEF-3 antibody, Transcriptional enhancer factor TEF3 antibody

UniProt: Q15561

Pathways: Regulation of Lipid Metabolism by PPARalpha