TMEM64 antibody (AA 40-118) (FITC)
Quick Overview for TMEM64 antibody (AA 40-118) (FITC) (ABIN7173259)
Target
Reactivity
Host
Clonality
Conjugate
Application
-
-
Binding Specificity
- AA 40-118
-
Cross-Reactivity
- Human
-
Purification
- >95%, Protein G purified
-
Immunogen
- Recombinant Human Transmembrane protein 64 protein (40-118AA)
-
Isotype
- IgG
-
-
anti-Transmembrane Protein 64 (TMEM64) (AA 40-118) antibody
TMEM64 Reactivity: Human ELISA, IHC, WB Host: Rabbit Polyclonal unconjugated
-
-
Restrictions
- For Research Use only
-
-
-
Format
- Liquid
-
Buffer
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
Preservative
- ProClin
-
Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Storage
- -20 °C,-80 °C
-
Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- TMEM64 (Transmembrane Protein 64 (TMEM64))
-
Alternative Name
- TMEM64
-
Background
-
Background: Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1.
Aliases: TMEM64 antibody, TMM64_HUMAN antibody, Transmembrane protein 64 antibody
-
UniProt
- Q6YI46
Target
-
