RANKL antibody (AA 73-306)

Catalog No. ABIN7173790

This anti-RANKL antibody is a Rabbit Polyclonal antibody detecting RANKL in ELISA, IHC and IF. Suitable for Human.

Quick Overview for RANKL antibody (AA 73-306) (ABIN7173790)

Target: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RANKL antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-RANKL Antibody

Binding Specificity: AA 73-306

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Tumor necrosis factor ligand superfamily member 11 protein (73-306AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RANKL

Target: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Alternative Name: TNFSF11

Background:

Background: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity).

Aliases: CD254 antibody, hRANKL2 antibody, ODF antibody, OPGL antibody, OPTB2 antibody, Osteoclast differentiation factor antibody, Osteoprotegerin ligand antibody, RANKL antibody, Receptor activator of NF-kappa-B ligand antibody, Receptor activator of nuclear factor kappa B ligand antibody, Receptor activator of nuclear factor kappa-B ligand antibody, sOdf antibody, soluble form antibody, TNF-related activation-induced cytokine antibody, TNF11_HUMAN antibody, Tnfsf11 antibody, TRANCE antibody, Tumor necrosis factor (ligand) superfamily member 11 antibody, Tumor necrosis factor ligand superfamily member 11 antibody

UniProt: O14788

Pathways: NF-kappaB Signaling