TWIST1 antibody (AA 1-80)

Catalog No. ABIN7173945

The Rabbit Polyclonal anti-TWIST1 antibody has been validated for WB and ELISA. It is suitable to detect TWIST1 in samples from Human.

Quick Overview for TWIST1 antibody (AA 1-80) (ABIN7173945)

Target: TWIST1 (Twist Homolog 1 (Drosophila) (TWIST1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TWIST1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TWIST1 Antibody

Binding Specificity: AA 1-80

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Twist-related protein 1 protein (1-80AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TWIST1

Target: TWIST1 (Twist Homolog 1 (Drosophila) (TWIST1))

Alternative Name: TWIST1

Background:

Background: Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity).

Aliases: ACS3 antibody, B-HLH DNA binding protein antibody, bHLHa38 antibody, BPES2 antibody, BPES3 antibody, Class A basic helix-loop-helix protein 38 antibody, CRS antibody, CRS1 antibody, CSO antibody, H-twist antibody, OTTHUMP00000116043 antibody, SCS antibody, Twist basic helix loop helix transcription factor 1 antibody, Twist family bHLH transcription factor 1 antibody, Twist homolog 1 (Drosophila) antibody, Twist homolog 1 antibody, TWIST homolog of drosophila antibody, Twist related protein 1 antibody, Twist-related protein 1 antibody, TWIST1 antibody, TWST1_HUMAN antibody

UniProt: Q15672

Pathways: p53 Signaling, Proton Transport, Tube Formation, Negative Regulation of Transporter Activity