FES antibody (AA 120-420)

Catalog No. ABIN7174019

This Rabbit Polyclonal antibody specifically detects FES in ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for FES antibody (AA 120-420) (ABIN7174019)

Target: FES (Feline Sarcoma Oncogene (FES))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FES antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-FES Antibody

Binding Specificity: AA 120-420

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Tyrosine-protein kinase Fes/Fps protein (120-420AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FES

Target: FES (Feline Sarcoma Oncogene (FES))

Alternative Name: FES

Background:

Background: Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.

Aliases: c-fes/fps protein antibody, cFES antibody, Feline sarcoma (Snyder Theilen) viral (v fes)/Fujinami avian sarcoma (PRCII) viral (v fps) oncogene homolog antibody, feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami antibody, Feline sarcoma oncogene antibody, Feline sarcoma/Fujinami avian sarcoma oncogene homolog antibody, fes antibody, FES proto oncogene, tyrosine kinase antibody, FES_HUMAN antibody, FPS antibody, Oncogene FES antibody, Oncogene FES feline sarcoma virus antibody, P93c fes antibody, Proto oncogene tyrosine protein kinase Fes/Fps antibody, Proto-oncogene c-Fes antibody, Proto-oncogene c-Fps antibody, proto-oncogene tyrosine-protein kinase Fes/Fps antibody, Tyrosine-protein kinase Fes/Fps antibody

UniProt: P07332

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Signaling Events mediated by VEGFR1 and VEGFR2