Ubiquilin 2 antibody (AA 473-542)

Catalog No. ABIN7174228

Product Details anti-Ubiquilin 2 Antibody

Target: Ubiquilin 2 (UBQLN2)

Binding Specificity: AA 473-542

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ubiquilin 2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquilin-2 protein (473-542AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Ubiquilin 2

Target: Ubiquilin 2 (UBQLN2)

Alternative Name: UBQLN2 (UBQLN2 Products)

Synonyms: ALS15 antibody, CHAP1 antibody, DSK2 antibody, N4BP4 antibody, PLIC2 antibody, Chap1 antibody, Dsk2 antibody, HRIHFB2157 antibody, Plic-2 antibody, Plic2 antibody, RGD1563566 antibody, UBQLN2 antibody, ubiquilin 2 antibody, UBQLN2 antibody, Ubqln2 antibody

Background:

Background: Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation, required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683).

Aliases: UBQLN2 antibody, N4BP4 antibody, PLIC2 antibody, HRIHFB2157Ubiquilin-2 antibody, Chap1 antibody, DSK2 homolog antibody, Protein linking IAP with cytoskeleton 2 antibody, PLIC-2 antibody, hPLIC-2 antibody, Ubiquitin-like product Chap1/Dsk2 antibody

UniProt: Q9UHD9