UBE2K antibody (AA 2-200)

Catalog No. ABIN7174460

Product Details anti-UBE2K Antibody

Target: UBE2K (Ubiquitin-Conjugating Enzyme E2K (UBE2K))

Binding Specificity: AA 2-200

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBE2K antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquitin-conjugating enzyme E2 K protein (2-200AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:10-1:100, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for UBE2K

Target: UBE2K (Ubiquitin-Conjugating Enzyme E2K (UBE2K))

Alternative Name: UBE2K (UBE2K Products)

Synonyms: E2-25K antibody, HIP2 antibody, HYPG antibody, LIG antibody, UBC1 antibody, E2-25k antibody, Hip2 antibody, Hypg antibody, Lig antibody, e2-25k antibody, hip2 antibody, hypg antibody, lig antibody, AW492011 antibody, D5Ertd601e antibody, ube2k antibody, zgc:103472 antibody, zgc:110791 antibody, ubiquitin conjugating enzyme E2 K antibody, ubiquitin-conjugating enzyme E2K antibody, ubiquitin conjugating enzyme E2 K S homeolog antibody, ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast) antibody, ubiquitin-conjugating enzyme E2Ka (UBC1 homolog, yeast) antibody, UBE2K antibody, Ube2k antibody, ube2k.S antibody, ube2k antibody, ube2kb antibody, ube2ka antibody

Background:

Background: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of \\\'Lys-48\\\'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B, in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.

Aliases: E2 25K antibody, E2(25K) antibody, HIP-2 antibody, Huntingtin interacting protein 2 antibody, Huntingtin-interacting protein 2 antibody, HYPG antibody, LIG antibody, UBC1 antibody, UBE2K antibody, UBE2K_HUMAN antibody, Ubiquitin carrier protein antibody, Ubiquitin conjugating enzyme E2 25 kDa antibody, ubiquitin conjugating enzyme E2K antibody, ubiquitin conjugating enzyme E2K (UBC1 homolog, yeast) antibody, Ubiquitin protein ligase antibody, Ubiquitin-conjugating enzyme E2 K antibody, Ubiquitin-conjugating enzyme E2(25K) antibody, Ubiquitin-conjugating enzyme E2-25 kDa antibody, Ubiquitin-conjugating enzyme E2-25K antibody, Ubiquitin-protein ligase antibody

UniProt: P61086