UBE2L3 antibody (AA 1-154) (Biotin)

Catalog No. ABIN7174469

This Rabbit Polyclonal antibody specifically detects UBE2L3 in ELISA. It exhibits reactivity toward Human.

Quick Overview for UBE2L3 antibody (AA 1-154) (Biotin) (ABIN7174469)

Target: UBE2L3 (Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBE2L3 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-UBE2L3 Antibody (Biotin)

Binding Specificity: AA 1-154

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquitin-conjugating enzyme E2 L3 protein (1-154AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for UBE2L3

Target: UBE2L3 (Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3))

Alternative Name: UBE2L3

Background:

Background: Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes \'Lys-11\'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.

Aliases: E2 F1 antibody, L UBC antibody, L-UBC antibody, UB2L3_HUMAN antibody, UBCE7 antibody, UbcH7 antibody, UbcM4 antibody, Ube2l3 antibody, Ubiquitin carrier protein L3 antibody, Ubiquitin conjugating enzyme E2 L3 antibody, Ubiquitin protein ligase L3 antibody, Ubiquitin-conjugating enzyme E2 L3 antibody, Ubiquitin-conjugating enzyme E2-F1 antibody, Ubiquitin-protein ligase L3 antibody

UniProt: P68036