ULBP1 antibody (AA 26-216) (Biotin)

Catalog No. ABIN7174679

This Rabbit Polyclonal antibody specifically detects ULBP1 in ELISA. It exhibits reactivity toward Human.

Quick Overview for ULBP1 antibody (AA 26-216) (Biotin) (ABIN7174679)

Target: ULBP1 (UL16 Binding Protein 1 (ULBP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ULBP1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-ULBP1 Antibody (Biotin)

Binding Specificity: AA 26-216

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human UL16-binding protein 1 protein (26-216AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ULBP1

Target: ULBP1 (UL16 Binding Protein 1 (ULBP1))

Alternative Name: ULBP1

Background:

Background: Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Aliases: Alcan beta antibody, ALCAN-beta antibody, N2DL-1 antibody, N2DL1 antibody, N2DL1_HUMAN antibody, NKG2D ligand 1 antibody, NKG2D ligand 1 precursor antibody, NKG2DL1 antibody, RAET1I antibody, Retinoic acid early transcript 1I antibody, UL16 antibody, UL16 binding protein 1 antibody, UL16-binding protein 1 antibody, ULBP1 antibody

UniProt: Q9BZM6

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process