Myosin XVIIIA antibody (AA 1849-2054) (HRP)

Catalog No. ABIN7174984

This anti-Myosin XVIIIA antibody is a Rabbit Polyclonal antibody detecting Myosin XVIIIA in ELISA. Suitable for Human.

Quick Overview for Myosin XVIIIA antibody (AA 1849-2054) (HRP) (ABIN7174984)

Target: Myosin XVIIIA (MYO18A)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Myosin XVIIIA antibody is conjugated to HRP

Application: ELISA

Product Details anti-Myosin XVIIIA Antibody (HRP)

Binding Specificity: AA 1849-2054

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Unconventional myosin-XVIIIa protein (1849-2054AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Myosin XVIIIA

Target: Myosin XVIIIA (MYO18A)

Alternative Name: MYO18A

Background:

Background: May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939).

Aliases: MYO18A antibody, CD245 antibody, KIAA0216 antibody, MYSPDZ antibody, Unconventional myosin-XVIIIa antibody, Molecule associated with JAK3 N-terminus antibody, MAJN antibody, Myosin containing a PDZ domain antibody, Surfactant protein receptor SP-R210 antibody, SP-R210 antibody

UniProt: Q92614