UVSSA/KIAA1530 antibody (AA 143-206) (HRP)

Catalog No. ABIN7175185

This anti-UVSSA/KIAA1530 antibody is a Rabbit Polyclonal antibody detecting UVSSA/KIAA1530 in ELISA. Suitable for Human.

Quick Overview for UVSSA/KIAA1530 antibody (AA 143-206) (HRP) (ABIN7175185)

Target: UVSSA/KIAA1530 (UVSSA) (UV Stimulated Scaffold Protein A (UVSSA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UVSSA/KIAA1530 antibody is conjugated to HRP

Application: ELISA

Product Details anti-UVSSA/KIAA1530 Antibody (HRP)

Binding Specificity: AA 143-206

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human UV-stimulated scaffold protein A protein (143-206AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for UVSSA/KIAA1530

Target: UVSSA/KIAA1530 (UVSSA) (UV Stimulated Scaffold Protein A (UVSSA))

Alternative Name: UVSSA

Background:

Background: Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.

Aliases: hypothetical protein LOC57654 antibody, K1530_HUMAN antibody, KIAA1530 antibody, Uncharacterized protein KIAA1530 antibody, UV stimulated scaffold protein A antibody, UVSS3 antibody, UVSSA antibody

UniProt: Q2YD98