WDFY2 antibody (AA 2-114) (Biotin)

Catalog No. ABIN7175696

This Rabbit Polyclonal antibody specifically detects WDFY2 in ELISA. It exhibits reactivity toward Human.

Quick Overview for WDFY2 antibody (AA 2-114) (Biotin) (ABIN7175696)

Target: WDFY2 (ZFYVE22) (Zinc Finger, FYVE Domain Containing 22 (ZFYVE22))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WDFY2 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-WDFY2 Antibody (Biotin)

Binding Specificity: AA 2-114

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human WD repeat and FYVE domain-containing protein 2 protein (2-114AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for WDFY2

Target: WDFY2 (ZFYVE22) (Zinc Finger, FYVE Domain Containing 22 (ZFYVE22))

Alternative Name: WDFY2

Background:

Background: Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling, required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553).

Aliases: PROF antibody, Propeller-FYVE protein antibody, RP11 147H23.1 antibody, WD repeat and FYVE domain containing 2 antibody, WD repeat and FYVE domain-containing protein 2 antibody, WD40 and FYVE domain containing 2 antibody, WD40- and FYVE domain-containing protein 2 antibody, WDF2 antibody, Wdfy2 antibody, WDFY2_HUMAN antibody, ZFYVE22 antibody, Zinc finger FYVE domain-containing protein 22 antibody

UniProt: Q96P53