PDK3 antibody (AA 131-362) (Biotin)

Catalog No. ABIN7176881

This Rabbit Polyclonal antibody specifically detects PDK3 in ELISA. It exhibits reactivity toward Mouse.

Quick Overview for PDK3 antibody (AA 131-362) (Biotin) (ABIN7176881)

Target: PDK3 (Pyruvate Dehydrogenase Kinase, Isozyme 3 (PDK3))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDK3 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-PDK3 Antibody (Biotin)

Binding Specificity: AA 131-362

Cross-Reactivity: Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Mouse [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial protein (131-362AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PDK3

Target: PDK3 (Pyruvate Dehydrogenase Kinase, Isozyme 3 (PDK3))

Alternative Name: Pdk3

Background:

Background: Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species (By similarity).

Aliases: Pdk3 antibody, [Pyruvate dehydrogenase antibody, acetyl-transferring)] kinase isozyme 3 antibody, mitochondrial antibody, EC 2.7.11.2 antibody, Pyruvate dehydrogenase kinase isoform 3 antibody

UniProt: Q922H2

Pathways: PI3K-Akt Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect