MMP2 antibody (AA 412-662) (FITC)

Catalog No. ABIN7176886

This anti-MMP2 antibody is a Rabbit Polyclonal antibody detecting MMP2 in . Suitable for Mouse.

Quick Overview for MMP2 antibody (AA 412-662) (FITC) (ABIN7176886)

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP2 antibody is conjugated to FITC

Application: Please inquire

Product Details anti-MMP2 Antibody (FITC)

Binding Specificity: AA 412-662

Cross-Reactivity: Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Mouse 72 kDa type IV collagenase protein (412-662AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MMP2

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Alternative Name: Mmp2

Background:

Background: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues (By similarity).By similarity PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta-3 on the surface of blood vessels (By similarity).By similarity Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

Aliases: Mmp2 antibody, 72 kDa type IV collagenase antibody, EC 3.4.24.24 antibody, 72 kDa gelatinase antibody, Gelatinase A antibody, Matrix metalloproteinase-2 antibody, MMP-2) [Cleaved into: PEX] antibody

UniProt: P33434

Pathways: Activation of Innate immune Response