MMP13 antibody (AA 105-472)

Catalog No. ABIN7177113

Product Details anti-MMP13 Antibody

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Binding Specificity: AA 105-472

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP13 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Mouse Collagenase 3 protein (105-472AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:200-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MMP13

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Alternative Name: Mmp13 (MMP13 Products)

Synonyms: CLG3 antibody, MANDP1 antibody, Clg antibody, MMP-13 antibody, Mmp1 antibody, cb1034 antibody, mmp13 antibody, gene A antibody, xCol antibody, xcl3 antibody, MMP13 antibody, MGC108008 antibody, matrix metallopeptidase 13 antibody, matrix metallopeptidase 13a antibody, matrix metallopeptidase 13 (collagenase 3) like S homeolog antibody, matrix metallopeptidase 13 (collagenase 3) antibody, matrix metalloproteinase 13 antibody, matrix metallopeptidase 13 (collagenase 3) like L homeolog antibody, MMP13 antibody, Mmp13 antibody, mmp13a antibody, mmp13l.S antibody, mmp13 antibody, LOC100136348 antibody, mmp13l.L antibody

Background:

Background: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.

Aliases: Mmp13 antibody, Collagenase 3 antibody, EC 3.4.24.- antibody, Matrix metalloproteinase-13 antibody, MMP-13 antibody

UniProt: P33435