WSS1 (AA 1-269) antibody (Biotin)
Quick Overview for WSS1 (AA 1-269) antibody (Biotin) (ABIN7179221)
Target
Reactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 1-269
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Purpose
- WSS1 Antibody, Biotin conjugated
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Cross-Reactivity
- Saccharomyces cerevisiae
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Purification
- Protein G purified
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Purity
- >95 %
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Immunogen
- Recombinant Saccharomyces cerevisiae DNA-dependent metalloprotease WSS1 protein (1-269AA)
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Isotype
- IgG
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- WSS1
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Background
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Background: Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped TOP1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites.
Aliases: WSS1 antibody, YHR134WDNA-dependent metalloprotease WSS1 antibody, EC 3.4.24.- antibody, DNA damage response protein WSS1 antibody, SUMO-dependent isopeptidase WSS1 antibody, Weak suppressor of SMT3 protein 1 antibody
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UniProt
- P38838
Target
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