Notch1 antibody (AA 21-338) (Biotin)

Catalog No. ABIN7179799

This anti-Notch1 antibody is a Rabbit Polyclonal antibody detecting Notch1 in ELISA. Suitable for Zebrafish (Danio rerio).

Quick Overview for Notch1 antibody (AA 21-338) (Biotin) (ABIN7179799)

Target: Notch1 (NOTCH1) (Notch 1 (NOTCH1))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Notch1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-Notch1 Antibody (Biotin)

Binding Specificity: AA 21-338

Cross-Reactivity: Zebrafish (Danio rerio)

Purification: >95%, Protein G purified

Immunogen: Recombinant Zebrafish Neurogenic locus notch homolog protein 1 protein (21-338AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Notch1

Target: Notch1 (NOTCH1) (Notch 1 (NOTCH1))

Alternative Name: notch1a

Background:

Background: Functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis, negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis (By similarity). Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity).

Aliases: notch1a antibody, notch antibody, Neurogenic locus notch homolog protein 1 antibody, Notch 1) [Cleaved into: Notch 1 extracellular truncation antibody, NEXT), Notch 1 intracellular domain antibody, NICD)] antibody

UniProt: P46530

Pathways: Notch Signaling, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development