Sonic Hedgehog antibody (AA 24-197)

Catalog No. ABIN7179866

This Rabbit Polyclonal antibody specifically detects Sonic Hedgehog in ELISA. It exhibits reactivity toward Zebrafish (Danio rerio).

Quick Overview for Sonic Hedgehog antibody (AA 24-197) (ABIN7179866)

Target: Sonic Hedgehog (SHH)

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Sonic Hedgehog antibody is un-conjugated

Application: ELISA

Product Details anti-Sonic Hedgehog Antibody

Binding Specificity: AA 24-197

Cross-Reactivity: Zebrafish (Danio rerio)

Purification: >95%, Protein G purified

Immunogen: Recombinant Zebrafish Sonic hedgehog protein A protein (24-197AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Sonic Hedgehog

Target: Sonic Hedgehog (SHH)

Alternative Name: shha

Background:

Background: Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning, dorso-ventral patterning of the brain and early patterning of the developing eyes. Displays floor plate-inducing activity. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO (By similarity).

Aliases: shha antibody, shh antibody, vhh1 antibody, Sonic hedgehog protein A antibody, SHHA antibody, Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains antibody, ShhNC antibody, VHH-1) [Cleaved into: Sonic hedgehog protein A N-product antibody, Shh N-terminal processed signaling domains antibody, ShhNp antibody, Sonic hedgehog protein N-product antibody, ShhN)] antibody

UniProt: Q92008

Pathways: Hedgehog Signaling, Dopaminergic Neurogenesis, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development