VAV1 antibody (Tyr174)

Catalog No. ABIN7180104

The Rabbit Polyclonal anti-VAV1 antibody has been validated for WB, ELISA and IHC. It is suitable to detect VAV1 in samples from Human.

Quick Overview for VAV1 antibody (Tyr174) (ABIN7180104)

Target: VAV1 (Vav 1 Oncogene (VAV1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VAV1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-VAV1 Antibody

Binding Specificity: Tyr174

Cross-Reactivity: Human, Mouse

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized non-phosphopeptide derived from Human VAV1 around the phosphorylation site of tyrosine 174 (E-I-Y-E-D).

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for VAV1

Target: VAV1 (Vav 1 Oncogene (VAV1))

Alternative Name: VAV1

Background:

Background: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

Ana V. Miletic, J. Biol. Chem., Dec 2006, 281: 38257 - 38265.
Christopher C. Stebbins, Mol. Cell. Biol., Sep 2003, 23: 6291 - 6299.
Vered Schapira, Cancer Res., Jun 2006, 66: 6183 - 6191.
Maya Groysman, J. Biol. Chem., Dec 2002, 277: 50121 - 50130.

Aliases: Oncogene vav antibody, p95Vav antibody, Proto-oncogene vav antibody, Protooncogene vav antibody, VAV 1 antibody, VAV 1 oncogene antibody, VAV antibody, Vav proto oncogene antibody, VAV_HUMAN antibody, VAV1 antibody

UniProt: P15498

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, BCR Signaling