AKR1A1 antibody (C-Term)

Catalog No. ABIN7180116

The Rabbit Polyclonal anti-AKR1A1 antibody is suitable to detect AKR1A1 in samples from Human. It has been validated for WB and ELISA.

Quick Overview for AKR1A1 antibody (C-Term) (ABIN7180116)

Target: AKR1A1 (Aldo-Keto Reductase Family 1, Member A1 (Aldehyde Reductase) (AKR1A1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKR1A1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-AKR1A1 Antibody

Binding Specificity: C-Term

Purpose: AKR1A1 Antibody

Cross-Reactivity: Mouse, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from C-terminal of Human AKR1A1.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for AKR1A1

Target: AKR1A1 (Aldo-Keto Reductase Family 1, Member A1 (Aldehyde Reductase) (AKR1A1))

Alternative Name: AKR1A1

Background:

Background: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).

Bohren K.M., J. Biol. Chem. 264:9547-9551(1989).
Fujii J., Cytogenet. Cell Genet. 84:230-232(1999).
Barski O.A., Genomics 60:188-198(1999).

Aliases: AK1A1_HUMAN antibody, Akr1a1 antibody, Alcohol dehydrogenase [NADP+] antibody, Alcohol dehydrogenase antibody, Aldehyde reductase antibody, Aldo keto reductase family 1 member A1 (aldehyde reductase) antibody, Aldo-keto reductase family 1 member A1 antibody, ALDR1 antibody, ALR antibody, ARM antibody, DD3 antibody, MGC12529 antibody, MGC1380 antibody

UniProt: P14550

Pathways: Monocarboxylic Acid Catabolic Process