GRM8 antibody

Catalog No. ABIN7181343

The Rabbit Polyclonal anti-GRM8 antibody has been validated for WB, IHC and ELISA. It is suitable to detect GRM8 in samples from Human.

Quick Overview for GRM8 antibody (ABIN7181343)

Target: GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRM8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-GRM8 Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from Human GluR8.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GRM8

Target: GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))

Alternative Name: GRM8

Background:

Background: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Patrick. M. Downey, J Biomol Screen, Dec 2005, 10: 841 - 848.
RJ Wenthold, J. Biol. Chem., Jan 1994, 269: 1332 - 1339.
Toshiaki Watanabe, Cancer Res., Oct 2006, 66: 9804 - 9808.
V. Bruno, J. Neurosci., Sep 2000, 20: 6413.

Aliases: FLJ41058 antibody, GLUR8 antibody, Glutamate receptor metabotropic 8 antibody, GPRC1H antibody, GRM8 antibody, GRM8_HUMAN antibody, Metabotropic glutamate receptor 8 antibody, MGC126724 antibody, mGlu8 antibody, mGluR8 antibody

UniProt: O00222

Pathways: cAMP Metabolic Process, Synaptic Membrane