MARK2 antibody (pSer595)

Catalog No. ABIN714071

The Rabbit Polyclonal anti-MARK2 antibody has been validated for WB, IHC (p) and IF (p). It is suitable to detect MARK2 in samples from Human, Mouse and Rat.

Quick Overview for MARK2 antibody (pSer595) (ABIN714071)

Target: MARK2 (MAP/microtubule Affinity-Regulating Kinase 2 (MARK2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MARK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-MARK2 Antibody

Binding Specificity: pSer595

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human MARK2 around the phosphorylation site of Ser595

Isotype: IgG

Application Details

Application Notes: WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for MARK2

Target: MARK2 (MAP/microtubule Affinity-Regulating Kinase 2 (MARK2))

Alternative Name: Mark2

Background:

Synonyms: ELKL mot kinase 1, MARK2phospho S595, ELKL mot kinase, EMK-1, EMK1, MAP/microtubule affinity regulating kinase 2, MAP/microtubule affinity-regulating kinase 2, Mark2, MARK2_HUMAN, PAR1 homolog, Serine/threonine protein kinase MARK2, Serine/threonine-protein kinase MARK2.

Background: MARK2 refers to MAP/microtubule affinity-regulating kinase 2 isoform a [Homo sapiens]. EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule.stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1 called MARK2. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. Human MARK2 was shown to be encoded by a single mRNA ubiquitously expressed. This transcription variant includes the alternative exon in the coding region and therefore codes for a longer protein. Multiple splice variants exist for this protein.

Gene ID: 2011

UniProt: Q7KZI7

Pathways: SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection