MBTPS2 antibody

Catalog No. ABIN7183789

The Rabbit Polyclonal anti-MBTPS2 antibody (ABIN7183789) specifically detects MBTPS2 in ELISA and IF. The antibody is reactive with Human samples.

Quick Overview for MBTPS2 antibody (ABIN7183789)

Target: MBTPS2 (Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBTPS2 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Product Details anti-MBTPS2 Antibody

Purpose: MBTPS2 Antibody

Cross-Reactivity: Mouse

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from internal of Human MBTPS2.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MBTPS2

Target: MBTPS2 (Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2))

Alternative Name: MBTPS2

Background:

Background: Intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.

Rawson R.B., Mol. Cell 1:47-57(1997).
Ye J., Proc. Natl. Acad. Sci. U.S.A. 97:5123-5128(2000).

Aliases: BRESEK antibody, Endopeptidase S2P antibody, IFAP antibody, KFSDX antibody, MBTP2_HUMAN antibody, MBTPS2 antibody, Membrane bound transcription factor site 2 protease antibody, membrane-bound transcription factor peptidase, site 2 antibody, membrane-bound transcription factor protease, site 2 antibody, Membrane-bound transcription factor site-2 protease antibody, S2P antibody, S2P endopeptidase antibody, Site 2 protease antibody, SREBPs intramembrane protease antibody, Sterol regulatory element-binding proteins intramembrane protease antibody

UniProt: O43462

Pathways: ER-Nucleus Signaling