MBTPS2 antibody (AA 270-350)

Catalog No. ABIN7223014

This Rabbit Polyclonal antibody specifically detects MBTPS2 in ELISA, WB, IF and IP. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for MBTPS2 antibody (AA 270-350) (ABIN7223014)

Target: MBTPS2 (Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBTPS2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-MBTPS2 Antibody

Binding Specificity: AA 270-350

Purpose: Rabbit Anti-S2P Polyclonal Antibody

Specificity: S2P Polyclonal Antibody detects endogenous levels of S2P protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human S2P at AA range: 270-350

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IF 1:200-1:1000,ELISA 1:20000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MBTPS2

Target: MBTPS2 (Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2))

Alternative Name: S2P

Background: MBTPS2, S2P, Membrane-bound transcription factor site-2 protease, Endopeptidase S2P, Sterol regulatory element-binding proteins intramembrane protease, SREBPs intramembrane proteaseMBTPS2 (membrane bound transcription factor peptidase, site 2) encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in MBTPS2 have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome), IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.

Gene ID: 51360

UniProt: O43462

Pathways: ER-Nucleus Signaling