ARHGAP17 antibody

Catalog No. ABIN7184394

Product Details anti-ARHGAP17 Antibody

Target: ARHGAP17 (rho GTPase Activating Protein 17 (ARHGAP17))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGAP17 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human, Mouse, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from internal of HumanRHG17.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ARHGAP17

Target: ARHGAP17 (rho GTPase Activating Protein 17 (ARHGAP17))

Alternative Name: ARHGAP17 (ARHGAP17 Products)

Synonyms: MST066 antibody, MST110 antibody, MSTP038 antibody, MSTP066 antibody, MSTP110 antibody, NADRIN antibody, PP367 antibody, PP4534 antibody, RICH1 antibody, RICH1B antibody, WBP15 antibody, 5730403H17Rik antibody, Nadrin antibody, Nadrin2 antibody, Rich1 antibody, Wbp15 antibody, Rho GTPase activating protein 17 antibody, ARHGAP17 antibody, arhgap17 antibody, Arhgap17 antibody

Background:

Background: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca2+-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.

Richnau N., J. Biol. Chem. 276:35060-35070(2001).
Ota T., Nat. Genet. 36:40-45(2004).
The German cDNA consortium, Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.

Aliases: ARHGAP17 antibody, RICH1 antibody, MSTP066 antibody, MSTP110 antibody, Rho GTPase-activating protein 17 antibody, Rho-type GTPase-activating protein 17 antibody, RhoGAP interacting with CIP4 homologs protein 1 antibody, RICH-1 antibody

UniProt: Q68EM7