FGF23 antibody (AA 21-120)

Catalog No. ABIN714461

The Rabbit Polyclonal anti-FGF23 antibody has been validated for WB, ELISA, IHC (p), IF (cc), IF (p) and IHC (fro). It is suitable to detect FGF23 in samples from Rat. There are 2+ publications available.

Quick Overview for FGF23 antibody (AA 21-120) (ABIN714461)

Target: FGF23 (Fibroblast Growth Factor 23 (FGF23))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGF23 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-FGF23 Antibody

Binding Specificity: AA 21-120

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FGF23

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-FGF23 antibody (ABIN714461)

Schumacher, Alampour-Rajabi, Ponomariov, Curaj, Wu, Staudt, Rusu, Jankowski, Marx, Jankowski, Brandenburg, Liehn, Schuh: "Cardiac FGF23: new insights into the role and function of FGF23 after acute myocardial infarction." in: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, Vol. 40, pp. 47-54, (2019) (PubMed).

Andersen, Huntley, Sandberg, Heublein, Burnett: "Elevation of circulating but not myocardial FGF23 in human acute decompensated heart failure." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 31, Issue 5, pp. 767-72, (2016) (PubMed).

Target Details for FGF23

Target: FGF23 (Fibroblast Growth Factor 23 (FGF23))

Alternative Name: FGF23

Background:

Synonyms: ADHR, FGFN, HYPF, HPDR2, PHPTC, Fibroblast growth factor 23, FGF-23, Phosphatonin, Tumor-derived hypophosphatemia-inducing factor, FGF23, UNQ327/PRO9828

Background: Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.

Gene ID: 8074

UniProt: Q9GZV9

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion