SERPINA4 antibody (AA 161-220)

Catalog No. ABIN714731

There are 2+ publications for this product available. The Rabbit Polyclonal anti-SERPINA4 antibody is suitable to detect SERPINA4 in samples from Mouse. It has been validated for WB, ELISA, IHC (p), IF (cc), IF (p) and IHC (fro).

Quick Overview for SERPINA4 antibody (AA 161-220) (ABIN714731)

Target: SERPINA4 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4 (SERPINA4))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SERPINA4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-SERPINA4 Antibody

Binding Specificity: AA 161-220

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KLST/Kallistatin (161-220aa)

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-SERPINA4 antibody (ABIN714731)

Biswas, Maihofer, Mir, Rao, Zhang, Khandrika, Mahata, Friese, Hightower, Mahata, Baker, Nievergelt, Vaingankar, OConnor: "Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system." in: BMC medical genetics, Vol. 17, pp. 21, (2016) (PubMed).

Target Details for SERPINA4

Target: SERPINA4 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4 (SERPINA4))

Alternative Name: KLST

Background:

Synonyms: Serpin peptidase inhibitor clade A member 4, Kallikrein binding protein, Kallikrein inhibitor, Protease inhibitor 4, Serpin A4, KAL, Kallikrein binding protein, Kallikrein inhibitor, KBP, KLST, KST, MGC108582, PI4, Protease inhibitor 4, Serpin A4, Serpin peptidase inhibitor clade A member 4, SERPINA4, KAIN_HUMAN.

Background: Kallistatin is a serine proteinase inhibitor which binds to tissue kallikrein and inhibits its amidolytic and kininogenase activity. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein. Heparin blocks kallistatin's complex formation with tissue kallikrein and abolishes its inhibitory effect on tissue kallikrein's activity.

Gene ID: 5267