ABCC5 antibody

Catalog No. ABIN7189591

This Rabbit Polyclonal antibody specifically detects ABCC5 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for ABCC5 antibody (ABIN7189591)

Target: ABCC5 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 (ABCC5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCC5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-ABCC5 Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of Human ABCC5

Isotype: IgG

Application Details

Application Notes: ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ABCC5

Target: ABCC5 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 (ABCC5))

Alternative Name: ABCC5

Background:

Background: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected, however, the complete sequence and translation initiation site is unclear.

Aliases: ABC 33 antibody, ABC33 antibody, ABCC 5 antibody, Abcc5 antibody, ATP binding cassette sub family C (CFTR/MRP) member 5 antibody, ATP binding cassette sub family C member 5 antibody, ATP-binding cassette sub-family C member 5 antibody, Canalicular multispecific organic anion transporter C antibody, DKFZp686C1782 antibody, EST277145 antibody, MOAT C antibody, MOAT-C antibody, MOATC antibody, MRP 5 antibody, MRP5_HUMAN antibody, Multi specific organic anion tranporter C antibody, Multi-specific organic anion transporter C antibody, Multidrug resistance associated protein 5 antibody, Multidrug resistance-associated protein 5 antibody, pABC 11 antibody, pABC11 antibody, SMRP antibody

UniProt: O15440

Pathways: Glycosaminoglycan Metabolic Process