Bestrophin 1 antibody

Catalog No. ABIN7189978

This Rabbit Polyclonal antibody specifically detects Bestrophin 1 in WB, IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for Bestrophin 1 antibody (ABIN7189978)

Target: Bestrophin 1 (BEST1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Bestrophin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-Bestrophin 1 Antibody

Cross-Reactivity: Human, Mouse

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of Human BEST1

Isotype: IgG

Application Details

Application Notes: ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Bestrophin 1

Target: Bestrophin 1 (BEST1)

Alternative Name: BEST1

Background:

Background: This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.

Aliases: ARB antibody, BEST 1 antibody, BEST antibody, Best disease antibody, Best macular dystrophy antibody, BEST1 antibody, BEST1_HUMAN antibody, Best1V1Delta2 antibody, Bestrophin 1 antibody, Bestrophin-1 antibody, Bestrophin1 antibody, BMD antibody, mBest1 antibody, RP50 antibody, TU15B antibody, Vitelliform macular dystrophy 2 antibody, Vitelliform macular dystrophy antibody, Vitelliform macular dystrophy protein 2 antibody, VMD 2 antibody, VMD2 antibody

UniProt: O76090