Metabotropic Glutamate Receptor 1 antibody

Catalog No. ABIN7190883

This anti-Metabotropic Glutamate Receptor 1 antibody is a Rabbit Polyclonal antibody detecting Metabotropic Glutamate Receptor 1 in WB, IHC and ELISA. Suitable for Human.

Quick Overview for Metabotropic Glutamate Receptor 1 antibody (ABIN7190883)

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Metabotropic Glutamate Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-Metabotropic Glutamate Receptor 1 Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of Human GRM1

Isotype: IgG

Application Details

Application Notes: ELISA:1:1000-1:5000, WB:1:500-1:2000, IHC:1:15-1:50,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Metabotropic Glutamate Receptor 1

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Alternative Name: GRM1

Background:

Background: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms, some of which may have distinct functions.

Aliases: Glutamate receptor metabotropic 1 antibody, glutamate receptor, metabotropic 1 antibody, GPRC1A antibody, GRM1 antibody, GRM1-Alpha antibody, GRM1_HUMAN antibody, GRM1A antibody, Metabotropic glutamate receptor 1 antibody, mGlu1 antibody, mGluR1 antibody, MGLUR1-Alpha antibody, MGLUR1A antibody, SCAR13 antibody

UniProt: Q13255