MED14 antibody

Catalog No. ABIN7191443

The Rabbit Polyclonal anti-MED14 antibody has been validated for ELISA and IHC. It is suitable to detect MED14 in samples from Human.

Quick Overview for MED14 antibody (ABIN7191443)

Target: MED14 (Mediator Complex Subunit 14 (MED14))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MED14 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-MED14 Antibody

Cross-Reactivity: Human

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of Human MED14

Isotype: IgG

Application Details

Application Notes: ELISA:1:2000-1:5000, IHC:1:25-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MED14

Target: MED14 (Mediator Complex Subunit 14 (MED14))

Alternative Name: MED14

Background:

Background: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.

Aliases: Activator-recruited cofactor 150 kDa component antibody, ARC150 antibody, Cofactor required for Sp1 transcriptional activation subunit 2 antibody, CRSP complex subunit 2 antibody, DRIP150 antibody, EXLM1 antibody, hRGR1 antibody, MED14 antibody, MED14_HUMAN antibody, Mediator complex subunit 14 antibody, Mediator of RNA polymerase II transcription subunit 14 antibody, RGR1 antibody, RGR1 homolog antibody, Thyroid hormone receptor-associated protein complex 170 kDa component antibody, Transcriptional coactivator CRSP150 antibody, Trap170 antibody, Vitamin D3 receptor-interacting protein complex 150 kDa component antibody

UniProt: O60244

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha