BIRC3 antibody (AA 511-604) (HRP)

Catalog No. ABIN714995

The Rabbit Polyclonal anti-BIRC3 antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect BIRC3 in samples from Human and Mouse.

Quick Overview for BIRC3 antibody (AA 511-604) (HRP) (ABIN714995)

Target: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BIRC3 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-BIRC3 Antibody (HRP)

Binding Specificity: AA 511-604

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human cIAP2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for BIRC3

Target: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Alternative Name: API2

Background:

Synonyms: CIAP 2, CIAP-2, Inhibitor of apoptosis protein 1, AIP 1, AIP1, API 2, API2, Apoptosis inhibitor 2, Baculoviral IAP repeat containing 3, Baculoviral IAP repeat containing protein 3, Baculoviral IAP repeat-containing protein 3, BIRC 3, BIRC3, BIRC3_HUMAN, C IAP2, C-IAP2, CIAP 2, CIAP2, HAIP 1, HAIP1, HIAP 1, HIAP-1, HIAP1, IAP homolog C, IAP-1, Inhibitor of apoptosis protein 1, MALT 2, MALT2, Mammalian IAP homolog C, MIHC, RING finger protein 49, RNF49, TNFR2 TRAF signaling complex protein 1, TNFR2 TRAF signalling complex protein, TNFR2-TRAF-signaling complex protein 1.

Background: Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).

Gene ID: 330

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades