SPAG1 antibody

Catalog No. ABIN7192612

This Rabbit Polyclonal antibody specifically detects SPAG1 in ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for SPAG1 antibody (ABIN7192612)

Target: SPAG1 (Sperm Associated Antigen 1 (SPAG1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPAG1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-SPAG1 Antibody

Cross-Reactivity: Human

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of Human SPAG1

Isotype: IgG

Application Details

Application Notes: ELISA:1:1000-1:5000, IHC:1:25-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SPAG1

Target: SPAG1 (Sperm Associated Antigen 1 (SPAG1))

Alternative Name: SPAG1

Background:

Background: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.

Aliases: SPAG1 antibody, Sperm-associated antigen 1 antibody, HSD-3.8 antibody, Infertility-related sperm protein Spag-1 antibody

UniProt: Q07617