ATR antibody (AA 366-550)

Catalog No. ABIN7193431

This Mouse Monoclonal antibody specifically detects ATR in ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for ATR antibody (AA 366-550) (ABIN7193431)

Target: ATR (ATR serine/threonine kinase (ATR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ATR antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Clone: 3G6D2

Product Details anti-ATR Antibody

Binding Specificity: AA 366-550

Purpose: ATR Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human ATR (AA: 366-550) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for ATR

Target: ATR (ATR serine/threonine kinase (ATR))

Alternative Name: ATR

Background:

The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.

Molecular Weight: 301 kDa

Gene ID: 545

UniProt: Q13535

Pathways: Positive Regulation of Response to DNA Damage Stimulus