POLR2A/RPB1 antibody (AA 128-258)

Catalog No. ABIN7193495

The Mouse Monoclonal anti-POLR2A/RPB1 antibody has been validated for ELISA and FACS. It is suitable to detect POLR2A/RPB1 in samples from Human.

Quick Overview for POLR2A/RPB1 antibody (AA 128-258) (ABIN7193495)

Target: POLR2A/RPB1 (POLR2A) (RNA Polymerase II Subunit RPB1 (POLR2A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This POLR2A/RPB1 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Clone: 1B1D8

Product Details anti-POLR2A/RPB1 Antibody

Binding Specificity: AA 128-258

Purpose: POLR2A Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human POLR2A (AA: 128-258) expressed in E. Coli.

Isotype: IgG2b

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for POLR2A/RPB1

Target: POLR2A/RPB1 (POLR2A) (RNA Polymerase II Subunit RPB1 (POLR2A))

Alternative Name: POLR2A

Background:

This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.

Molecular Weight: 217 kDa

UniProt: P24928

Pathways: Regulatory RNA Pathways