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TLR7 antibody (AA 420-644)

This anti-TLR7 antibody is a Mouse Monoclonal antibody detecting TLR7 in ELISA, FACS and ICC. Suitable for Human.
Catalog No. ABIN7193967

Quick Overview for TLR7 antibody (AA 420-644) (ABIN7193967)

Target

See all TLR7 Antibodies
TLR7 (Toll-Like Receptor 7 (TLR7))

Reactivity

  • 95
  • 45
  • 9
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Host

  • 93
  • 19
Mouse

Clonality

  • 81
  • 30
  • 1
Monoclonal

Conjugate

  • 67
  • 8
  • 7
  • 6
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
This TLR7 antibody is un-conjugated

Application

  • 65
  • 48
  • 33
  • 17
  • 14
  • 10
  • 8
  • 7
  • 4
  • 3
  • 1
  • 1
ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone

4G1D4
  • Binding Specificity

    • 8
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 420-644

    Purpose

    TLR7 Antibody

    Purification

    Purified antibody

    Immunogen

    Purified recombinant fragment of human TLR7 (AA: 420-644) expressed in E. Coli.

    Isotype

    IgG2b
  • Application Notes

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    ICC: 1/50 - 1/200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    Purified antibody in PBS with 0.05 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Target

    TLR7 (Toll-Like Receptor 7 (TLR7))

    Alternative Name

    TLR7

    Background

    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign microorganisms, the various TLRs exhibit different patterns of expression as well, in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. This gene is predominantly expressed in lung, placenta, and spleen, and is phylogenetically related and lies in close proximity to another family member, TLR8, on chromosome X.

    Molecular Weight

    120 kDa

    Gene ID

    51284

    UniProt

    Q9NYK1

    Pathways

    TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades
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