Recombinant TNFSF11 (Denosumab Biosimilar) antibody
Reactivity: Human
FACS, in vivo
Host: Mouse
Monoclonal
unconjugated
Recombinant Antibody
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- Target See all TNFSF11 (Denosumab Biosimilar) products
- TNFSF11 (Denosumab Biosimilar)
- Antibody Type
- Recombinant Antibody
- Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This TNFSF11 (Denosumab Biosimilar) antibody is un-conjugated
- Application
- Flow Cytometry (FACS), In vivo Studies (in vivo)
- Purpose
- Denosumab Biosimilar, Human RANKL Monoclonal Antibody
- Specificity
- The monoclonal antibody denosumab biosimilar specifically binds to the human RANKL (RANK ligand) protein.
- Characteristics
- Recombinant Humanized IgG2 Monoclonal Antibody.
- Purification
- Protein A affinity column
- Purity
- > 95% by SDS-PAGE under reducing conditions and HPLC.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- < 1 EU per 1 mg of the protein by the LAL method.
- Immunogen
- The monoclonal antibody denosumab biosimilar was produced in the denosumab biosimilar CHO stable cell line.
- Isotype
- IgG2 kappa
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- Application Notes
- ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by denosumab.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, pH 7.4, no stabilizers or preservatives.
- Preservative
- Without preservative
- Handling Advice
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
- Expiry Date
- 12 months
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- Target
- TNFSF11 (Denosumab Biosimilar)
- Abstract
- TNFSF11 (Denosumab Biosimilar) Products
- Synonyms
- CD254 antibody, ODF antibody, OPGL antibody, OPTB2 antibody, RANKL antibody, TRANCE antibody, hRANKL2 antibody, sOdf antibody, TNF superfamily member 11 antibody, TNFSF11 antibody
- Target Type
- Biosimilar
- Background
- Denosumab, a fully human monoclonal antibody, inhibits the RANKL (RANK ligand) protein, the primary signal for bone removal. Denosumab can be used for the treatment of osteoporosis, treatment-induced bone loss, bone metastases, multiple myeloma, and giant cell tumor of bone.
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