AGXT2 antibody (AA 340-420)

Catalog No. ABIN7227242

The Rabbit Polyclonal anti-AGXT2 antibody is suitable to detect AGXT2 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for AGXT2 antibody (AA 340-420) (ABIN7227242)

Target: AGXT2 (Alanine Glyoxylate Aminotransferase 2 (AGXT2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AGXT2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-AGXT2 Antibody

Binding Specificity: AA 340-420

Purpose: Rabbit Anti-AGT2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of AGT2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human AGT2 protein at AA range: 340-420

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for AGXT2

Target: AGXT2 (Alanine Glyoxylate Aminotransferase 2 (AGXT2))

Alternative Name: AGT2

Background: Alanine--glyoxylate aminotransferase 2, mitochondrial, AGT 2, (R)-3-amino-2methylpropionate--pyruvate transaminase, Beta-ALAAT II, Beta-alanine-pyruvate aminotransferase, D-AIBATThe protein encoded by AGXT2 is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. It is an important regulator of methylarginines and is involved in the control of blood pressure in kidney. Polymorphisms in AGXT2 affect methylarginine and beta-aminoisobutyrate metabolism, and are associated with carotid atherosclerosis. Alternative splicing results in multiple transcript variants.

Molecular Weight: 56kD

Gene ID: 64902

UniProt: Q9BYV1

Pathways: Monocarboxylic Acid Catabolic Process