AK1C4 antibody (AA 1-80)

Catalog No. ABIN7227252

This Rabbit Polyclonal antibody specifically detects AK1C4 in ELISA and WB. It exhibits reactivity toward Human.

Quick Overview for AK1C4 antibody (AA 1-80) (ABIN7227252)

Target: AK1C4 (LOC105224584) (Aldo-Keto Reductase Family 1 Member C1 Homolog (LOC105224584))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AK1C4 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-AK1C4 Antibody

Binding Specificity: AA 1-80

Purpose: Rabbit Anti-AK1C4 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of AK1C4 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human AK1C4 protein at AA range: 1-80

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for AK1C4

Target: AK1C4 (LOC105224584) (Aldo-Keto Reductase Family 1 Member C1 Homolog (LOC105224584))

Alternative Name: AK1C4

Background: Aldo-keto reductase family 1 member C4, 3-alpha-HSD1, 3-alpha-hydroxysteroid dehydrogenase type I, Chlordecone reductase, CDR, Dihydrodiol dehydrogenase 4, DD-4, DD4AKR1C4 encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. AKR1C4 shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Molecular Weight: 35kD

Gene ID: 1109

UniProt: P17516